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Researchers found that participants investing in this drug for a year, lost weight within four weeks and have kept the weight off throughout the 56 weeks of the study. Contrave can be a combination of the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which are made up of several active ingredient, which may make them more effective and safer.

Combo-pilling will be the newest fad or in addition to this the newest in the future under scrutiny and so it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills is now popular could be the fact that as of right now there are no long term prescription weight loss supplements that have been authorized by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be licensed by the FDA.

Seizures can be a side effect with Contrave and must not be taken in people with seizure disorders. The drug also can raise blood pressure and heartrate, and must not be used in people with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must 't be used in patients with uncontrolled high blood pressure level, and also by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients having a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients for the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for quitting smoking.

"There were no warning signs of depression or suicidal thoughts in trial participants," said Fujioka.