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The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in older adults with a body mass index (BMI) in excess of 27, provided they also are afflicted by weight-related health issues such as Tupe2 diabestes, high-cholesterol and/or hypertension (high blood pressure levels).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder so when an aid to quitting smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle that features a reduced-calorie dieting and exercise, Contrave provides another treatment choice for chronic weight management for people who are obese or are overweight and still have at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular physical activity. Results from a medical trial that enrolled patients without diabetes indicated that patients had a typical weight loss of four.1% rather than participants who were given placebos) within a 12- month period, while another study involving patients with diabetes had the average weight loss of 2% over treatment with placebo at one full year.

Using two separate drugs to lose weight can be very effective you'll find combinations before the FDA now awaiting approval. When dealing with weight-loss and the those who go through it you should err on the side of caution and let the FDA do its job and demand some study be done so your public knows the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies come in business to make money and that they would say almost anything to keep people on their own medications.

Researchers discovered that participants investing in this drug to get a year, lost excess weight within one month and have kept the load off throughout the 56 weeks of the study. Contrave is a combination in the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs that are made up of more than one active ingredient, which can make them far better and safer.

Combo-pilling could be the newest fad or even better the newest to come under scrutiny and therefore it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that utilizing a combination of pills has become popular will be the fact that as of right now there aren't any long term prescription weightloss pills that have been licensed by the FDA besides orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be licensed by the FDA.

Seizures can be a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug may also raise blood pressure levels and heartrate, and mustn't be used in people who have a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise hypertension and heartrate and must not be used in patients with uncontrolled high hypertension, and also by a person with heart-related and cerebrovascular (circulation dysfunction impacting the brain) disease. Patients with a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert medical professionals and patients towards the increased likelihood of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking.


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