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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment choice for chronic weight-loss in addition to a reduced-calorie diet and physical activity.

Using two separate drugs to lose weight can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the those who go through it you need to err along the side of caution and permit the FDA do its job and demand some study be done in order that the public is aware of the side effects and risks of the medications before we take them. Keep in mind that drug companies are in business to generate income and that they would say everything to keep people on their medications.

Researchers found out that participants using this drug to get a year, dropped a few pounds within 4 weeks and have kept the extra weight off throughout the 56 weeks from the study. Contrave is really a combination in the drugs naltrexone and bupropion, which seems to reflect a fresh trend of weight-loss drugs which can be made up of more than one active ingredient, which may make them more effective and safer.

Combo-pilling will be the newest fad or even better the newest to come under scrutiny and therefore it is just more publicly known in recent months, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills has become popular will be the fact that by right now there aren't long term prescription weightloss pills that have been authorized by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be authorized by the FDA.

Seizures certainly are a side effect with Contrave and must not be taken in those with seizure disorders. The drug can also raise blood pressure and heartrate, and shouldn't be used in people with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise blood pressure level and heartbeat and must stop used in patients with uncontrolled high blood pressure level, along with by you aren't heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients which has a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert medical professionals and patients on the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation.

"This could be the first drug I'm conscious of that targets the appetite and reward centres within the brain," he was quoted saying.