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The U.S. Food and Drug Administration has approved using Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in grown-ups with a body mass index (BMI) of more than 27, given that they also have problems with weight-related health issues such as Tupe2 diabestes, high cholesterol levels and/or hypertension (blood pressure).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so when an aid to smoking cessation treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle that features a reduced-calorie diet and exercise, Contrave provides another treatment option for chronic weight-loss for people who are obese or are overweight and also have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated first year. All patients received lifestyle modification that contained a reduced- calorie diet and regular exercise. Results from a clinical study that enrolled patients without diabetes indicated that patients had a normal weight loss of four years old.1% rather than participants have been given placebos) during a 12- month period, while a different study involving patients with diabetes type 2 had an average weight loss of 2% over treatment with placebo at 12 months.

Using two separate drugs to lose weight can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with weight loss and the people that go through it you should err to the side of caution and permit the FDA do its job and demand some research be done in order that the public understands the side effects and dangers of the medications before we bring them. Keep in mind that drug companies will be in business to earn money and that they would say anything to keep people on their medications.

Researchers discovered that participants taking this drug for the year, dropped a few pounds within four weeks and have kept the weight off through the 56 weeks in the study. Contrave is a combination from the drugs naltrexone and bupropion, which usually reflect a fresh trend of weight-loss drugs which might be made up of multiple active ingredient, which might make them more potent and safer.

Combo-pilling will be the newest fad or in addition to this the newest in the future under scrutiny and therefore it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular may be the fact that at the time of right now there aren't long term prescription diet pills that have been approved by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be licensed by the FDA.

Seizures can be a side effect with Contrave and mustn't be taken in those with seizure disorders. The drug could also raise hypertension and heart rate, and really should not be used in individuals with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise blood pressure level and heart rate and must stop used in patients with uncontrolled high blood pressure level, in addition to by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients with a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients for the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking.

"There were no signs of depression or suicidal thoughts in trial participants," said Fujioka.