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The U.S. Food and Drug Administration has approved using Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in grown-ups with a body mass index (BMI) of more than 27, provided that they also have problems with weight-related health problems such as Tupe2 diabestes, high cholesterol levels and/or hypertension (blood pressure).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder so that as an aid to smoking cessation treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle that includes a reduced-calorie exercise and dieting, Contrave provides another treatment option for chronic weight-loss for people who are obese or are overweight and possess at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular exercise. Results from a clinical study that enrolled patients without diabetes demonstrated that patients had the average weight loss of 4.1% as opposed to participants who were given placebos) after a 12- month period, while a different study involving patients with diabetes had a normal weight loss of 2% over treatment with placebo at one full year.

Using two separate drugs to lose weight naturally can be very effective you can find combinations in front of the FDA now awaiting approval. When dealing with fat loss and the people who go through it one should err assisting caution and allow the FDA do its job and demand some study be done so your public is aware of the side effects and dangers of the medications before we bring them. Keep in mind that drug companies are in business to generate income and that they would say anything to keep people on their medications.

Researchers discovered that participants taking this drug for the year, lost weight within one month and have kept the load off through the entire 56 weeks from the study. Contrave is really a combination in the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs which can be made up of more than one active ingredient, that might make them far better and safer.

Combo-pilling is the newest fad or better yet the newest ahead under scrutiny and for that reason it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills has become popular is the fact that by right now there are not any long term prescription diet pills that have been licensed by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be licensed by the FDA.

Seizures really are a side effect with Contrave and shouldn't be taken in people who have seizure disorders. The drug could also raise hypertension and heartbeat, and really should not be used in people who have a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure and pulse rate and must not be used in patients with uncontrolled high blood pressure level, and also by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients using a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert medical professionals and patients towards the increased chance of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking.

"This could be the first drug I'm aware of that targets the appetite and reward centres inside brain," he was quoted saying.