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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in older adults with a body mass index (BMI) greater than 27, provided they also are afflicted by weight-related health concerns such as Tupe2 diabestes, high cholesterol levels and/or hypertension (hypertension).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder in addition to being an aid to stop smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle that features a reduced-calorie eating and working out, Contrave provides another treatment option for chronic weight management for people who are obese or are overweight and still have at least one weight-related health.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular physical activity. Results from a clinical trial that enrolled patients without diabetes established that patients had a typical weight loss of four years old.1% as opposed to participants who were given placebos) after a 12- month period, while a separate study involving patients with diabetes had the average weight loss of 2% over treatment with placebo at one year.

Using two separate drugs to lose weight can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight reduction and the people who go through it you need to err along the side of caution and permit the FDA do its job and demand some investigation be done in order that the public is aware of the side effects and perils associated with the medications before we take them. Keep in mind that drug companies come in business to make money and that they would say anything to keep people on their own medications.

Researchers found that participants investing in this drug for the year, dropped a few pounds within 4 weeks and have kept the weight off through the 56 weeks with the study. Contrave is a combination in the drugs naltrexone and bupropion, which usually reflect a fresh trend of weight-loss drugs that are made up of more than one active ingredient, which might make them more efficient and safer.

Combo-pilling may be the newest fad or even better the newest into the future under scrutiny and therefore it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills has become popular will be the fact that as of right now there are no long term prescription weight loss supplements that have been authorized by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be licensed by the FDA.

Seizures can be a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug may also raise blood pressure level and heart rate, and really should not be used in people who have a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise blood pressure level and heartbeat and must not used in patients with uncontrolled high blood pressure level, and also by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients having a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients to the increased risk of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.

--Participating in support groups that assist the family with the addict recover (for example Al-Anon or Nar-Anon).