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Researchers found out that participants using this drug for a year, dropped excess weight within a month and have kept the body weight off through the 56 weeks with the study. Contrave is really a combination with the drugs naltrexone and bupropion, which generally seems to reflect a whole new trend of weight-loss drugs which might be made up of several active ingredient, which might make them more potent and safer.

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Seizures really are a side effect with Contrave and mustn't be taken in those with seizure disorders. The drug could also raise hypertension and heartbeat, and shouldn't be used in people with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise blood pressure and heartbeat and must not used in patients with uncontrolled high blood pressure level, and also by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting the brain) disease. Patients which has a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients on the increased risk of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.

The most common adverse reactions reported with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.