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Evidence is increasing that addiction without exception is related to issues with the brain's reward center, particularly the mesolimbic system. This section of the problem regulates reward responses in acquiring food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both when they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to shed weight can be very effective you'll find combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the people that go through it you should err along the side of caution and allow the FDA do its job and demand some study be done so your public knows the side effects and risks of the medications before we drive them. Keep in mind that drug companies will be in business to earn money and that they would say everything to keep people on their own medications.

Researchers discovered that participants investing in this drug for any year, lost weight within one month and have kept the extra weight off through the entire 56 weeks of the study. Contrave can be a combination of the drugs naltrexone and bupropion, which usually reflect a brand new trend of weight-loss drugs which might be made up of many active ingredient, which might make them more potent and safer.

Combo-pilling will be the newest fad or also the newest into the future under scrutiny and so it is just more publicly known in recent months, comb-pilling for weight loss has been around since the eighties. The biggest reason that utilizing a combination of pills is starting to become popular may be the fact that at the time of right now there aren't any long term prescription diet pills that have been approved by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be approved by the FDA.

Seizures can be a side effect with Contrave and must not be taken in people with seizure disorders. The drug could also raise hypertension and heart rate, and must not be used in people with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise hypertension and heart rate and must not be used in patients with uncontrolled high blood pressure level, and also by you aren't heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients using a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients to the increased chance of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.

Most of the combinations which are used to enhance weight loss involve an amphetamine as well as an antidepressant. Phentermine and Prozac really are a popular combination that have been around for quite a while, and although it has been around stuffed to truly combine the two and try to get FDA approval to advertise it as a weight-loss pill. Right there should raise some warning flag if the greedy pharmaceutical companies do not want to be involved in combining medications and selling them something should be wrong using the combination. In fairness there is one weight-loss combination pill that is certainly in front of the FDA now Contrave?which couples naltrexone, used to treat alcohol and drug addiction, using the antidepressant bupropion (Wellbutrin, Zyban) it is often given the go ahead to move forward by an FDA advisory committee, but at the time of yet has not been approved.